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The sciatic nerve: a plain guide to the body's largest nerve

By the Life in Good Form editors. Updated 2026-10-13.

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Quick answerThe sciatic nerve is the largest nerve in the body, with one on each side. It forms from nerve roots in the lower spine (L4 to S3), passes through the buttock, runs down the back of the thigh and splits near the back of the knee into two branches that serve the lower leg and foot. It lets you move your legs and feet and feel touch, pain and temperature there. When its roots are pinched or irritated, usually by a slipped disc, the result is sciatica.
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Where the sciatic nerve starts and runs

StatPearls, the NIH-hosted medical reference, says the sciatic nerve arises from the ventral rami of spinal nerves L4 through S3: two roots from the lower back (lumbar) and three from the sacrum. These join in the pelvis, and the nerve leaves the pelvis through an opening called the greater sciatic foramen, usually passing below the piriformis muscle in the buttock.

From there it runs down the back of the thigh. Just above the back of the knee, it divides into two branches:

Cleveland Clinic adds that the nerve is narrow at the lower back and gets slightly wider down the leg; at its widest it is about the size of a penny.

What it does

Cleveland Clinic describes two jobs:

FunctionWhat it covers
Motor (movement)Helps the muscles of the legs and feet move. StatPearls lists the hamstrings at the back of the thigh, the calf muscles through the tibial branch, and the muscles that lift the foot and toes through the fibular branch.
Sensory (feeling)Lets you feel touch, pain and temperature. StatPearls says it supplies the skin of most of the lower leg and foot, except the inner side of the leg.

Cleveland Clinic notes that although the nerve passes through the buttock, it does not control the buttock muscles.

What can go wrong

Sciatica. Most problems start at the nerve roots in the spine. StatPearls says most sciatica has a spinal cause, such as a disc herniation affecting the L5 or S1 root. The NHS lists a slipped disc as the most common cause, along with spinal stenosis, spondylolisthesis and back injury. The result is pain, tingling, numbness or weakness down the back of one leg.

Piriformis problems. StatPearls says that in about 10% of people the nerve passes through or above the piriformis muscle rather than below it, and describes piriformis syndrome, in which the muscle compresses the nerve, with hip and buttock pain that worsens with sitting and driving.

Other causes. Mayo Clinic notes diabetes raises the risk of nerve damage, and StatPearls notes a poorly placed injection in the buttock can injure the nerve.

For what nerve pain actually feels like, see what sciatica feels like.

Looking after it

Prevention is not always possible, Mayo Clinic says, and sciatica can come back. The habits the sources agree on:

When sciatic nerve symptoms are an emergency

StatPearls says cauda equina syndrome, a serious compression of the nerve roots at the base of the spine, is suspected when there is urinary retention or altered sensation around the anus, and it needs prompt surgery. The NHS lists the signs to act on immediately: sciatica in both legs, severe or worsening weakness or numbness in both legs, numbness around or under the genitals or around the bottom, and new bladder or bowel problems. Full details are in sciatica warning signs.

What to look for when you buy

Lumbar support cushion

Best for: Long stretches of sitting at a desk or in the car

Mayo Clinic suggests good sitting posture with lower back support as one way to lower the risk of sciatica.

Watch out: Support is not a license to sit longer; get up regularly.

See options on Amazon

Sit-stand desk converter

Best for: Desk workers who sit most of the day

Cleveland Clinic says sitting too much and not moving enough may affect spine health, and Mayo Clinic lists prolonged sitting as a sciatica risk factor.

Watch out: Standing still all day is not the answer either; alternate and walk.

See options on Amazon

Firm exercise mat

Best for: Core and back exercises at home

Mayo Clinic points to regular exercise that strengthens the core and lower back as a prevention habit.

Watch out: If you already have sciatica, start gently and stop moves that send pain down the leg.

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When to talk to a doctor: See a doctor for leg pain, numbness or weakness that is severe, getting worse or not improving after a few weeks. Get emergency care for sciatica in both legs, numbness around the genitals or bottom, or any new bladder or bowel problem.

Questions people ask

Where is the sciatic nerve located?
It starts from nerve roots in the lower spine, passes through the buttock, and runs down the back of each thigh before splitting near the knee into branches for the lower leg and foot.
What nerve roots form the sciatic nerve?
StatPearls says it arises from spinal nerves L4 through S3.
How big is the sciatic nerve?
It is the largest nerve in the body. Cleveland Clinic says at its widest it is about the size of a penny.
What does the sciatic nerve control?
Movement in much of the leg and foot, including the hamstrings, calf and the muscles that lift the foot, plus feeling in most of the lower leg and foot.
Is sciatica a problem with the sciatic nerve itself?
Usually the trouble is at the nerve roots in the spine, often from a slipped disc. Cleveland Clinic also describes sciatica-like conditions involving nearby nerves that feel the same.

Sources

Sources checked 2026-10-13.