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Hydrocortisone cream 1%: uses, how often, and when not to use it

By the Life in Good Form editors. Updated 2026-10-15.

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Quick answerOver-the-counter hydrocortisone cream is a 1% corticosteroid for itch. Its Drug Facts label says it temporarily relieves itching from minor skin irritations, inflammation and rashes due to eczema, psoriasis, poison ivy, insect bites, soaps, cosmetics and jewelry, plus external anal and genital itching. Adults and children 2 and older can apply it to the affected area not more than 3 to 4 times daily. Do not use it for diaper rash, and stop and ask a doctor if symptoms last more than 7 days.
Our picks at a glance
  • Cortizone-10 Maximum Strength Soothing Aloe Cream. Best for: General itch from bites, plants and rashes. See options on Amazon
  • Vanicream HC Anti-Itch Cream 1%. Best for: People who prefer a short ingredient list. See options on Amazon
  • Store-brand hydrocortisone 1% cream. Best for: Keeping a tube in a first aid kit. See options on Amazon

Compare the picks and what to watch out for

What hydrocortisone cream does

Hydrocortisone belongs to a class of medicines called corticosteroids. MedlinePlus says topical hydrocortisone is used to treat redness, swelling, itching and discomfort of various skin conditions, and that it comes as an ointment, cream, solution, spray or lotion.

Over the counter, the label purpose is anti-itch. Cortizone-10 Maximum Strength and Vanicream HC both list hydrocortisone 1% as the active ingredient; Vanicream lists it as hydrocortisone acetate 1.12%, equivalent to hydrocortisone 1%.

What the label says it is for

Use on the labelWhoHow often
Itching from minor skin irritation, inflammation and rashesAdults and children 2 years and olderNot more than 3 to 4 times daily
External anal and genital itchingAdults; ask a doctor for children under 12Not more than 3 to 4 times daily, after gentle cleaning
Children under 2 yearsAsk a doctorDo not use without a doctor

Details are from the Cortizone-10 and Vanicream HC Drug Facts labels on DailyMed. The rash causes listed include eczema, psoriasis, poison ivy, oak and sumac, insect bites, detergents, jewelry, cosmetics, soaps and seborrheic dermatitis. Other uses should only be under a doctor's advice and supervision.

How to apply it

When not to use it

Tell your doctor or pharmacist before use if you are pregnant or breastfeeding, or have diabetes, MedlinePlus advises.

The 7-day rule and side effects

Stop use and ask a doctor if your condition worsens, if symptoms persist for more than 7 days, or if they clear up and occur again within a few days. Also stop and get help if rectal bleeding occurs. MedlinePlus likewise says that if over-the-counter hydrocortisone does not help within 7 days, stop using it and call your doctor.

MedlinePlus lists possible side effects including burning, itching, irritation, redness or dryness of the skin, acne, and skin color changes. Call a doctor right away for a severe rash or signs of skin infection where you applied it.

Other itch options

Hydrocortisone is one of several over-the-counter itch products. For itchy rashes from plants and bites, see our calamine lotion guide. For a non-steroid skin protectant for eczema and rashes, see our colloidal oatmeal lotion guide. For long-term eczema or psoriasis care, see our eczema cream and psoriasis cream guides.

Keep hydrocortisone out of reach of children. If someone swallows it, get medical help or contact a Poison Control Center right away.

What to look for when you buy

Cortizone-10 Maximum Strength Soothing Aloe Cream

Best for: General itch from bites, plants and rashes

Its label lists hydrocortisone 1% for itching from eczema, psoriasis, poison ivy, insect bites and more.

Watch out: Not more than 3 to 4 times daily; not for diaper rash.

See options on Amazon

Vanicream HC Anti-Itch Cream 1%

Best for: People who prefer a short ingredient list

Its label lists hydrocortisone acetate 1.12%, equivalent to hydrocortisone 1%, with the same anti-itch uses.

Watch out: Ask a doctor for children under 2.

See options on Amazon

Store-brand hydrocortisone 1% cream

Best for: Keeping a tube in a first aid kit

Several store brands sell 1% hydrocortisone cream; confirm the Drug Facts label lists hydrocortisone 1%.

Watch out: Check the active ingredient and directions on the box.

See options on Amazon
When to talk to a doctor: Do not use hydrocortisone for diaper rash, and ask a doctor before using it on children under 2. Stop and see a doctor if itching lasts more than 7 days, worsens, or shows signs of infection.

Questions people ask

What is hydrocortisone cream used for?
The label says temporary relief of itching from minor skin irritations, inflammation and rashes, plus external anal and genital itching.
How often can I use hydrocortisone cream?
Adults and children 2 and older: not more than 3 to 4 times daily.
How long can I use it?
Stop and ask a doctor if symptoms last more than 7 days or keep coming back.
Can I use hydrocortisone on a baby?
Ask a doctor for children under 2, and do not use it for diaper rash.
Can I use it on my face?
Keep it away from your eyes and mouth; ask a doctor before regular use on facial rashes.

Sources

Sources checked 2026-10-15.