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Cold sore cream

By the Life in Good Form editors. Updated 2026-10-15.

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Quick answerThe main over-the-counter cold sore treatment is docosanol 10% cream (Abreva), which the label says treats cold sores and fever blisters on the face or lips and shortens the time it takes for the sore to clear, along with tingling, pain, burning and itching. Start at the first tingle and apply 5 times a day. Abreva Rapid Pain Relief is a different product: lidocaine 4% with glycerin 20% to numb pain and itching and soften crusts, used up to 3 to 4 times daily. Wash hands before and after applying, do not share the tube, and see a doctor if the sore is not gone within 10 days.
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Docosanol cream vs lidocaine gel

DetailAbreva creamAbreva Rapid Pain Relief gel
Active ingredientsDocosanol 10%Lidocaine HCl 4% and glycerin 20%
PurposeCold sore and fever blister treatmentPain and itch relief; softens sores and crusts
How often (12 and over)5 times a day until the sore clearsNot more than 3 to 4 times daily
When to see a doctorSore worse or not cleared within 10 daysSymptoms last more than 7 days or keep returning

Details are from each product's DailyMed label. For children under 12, ask a doctor.

Start at the first tingle

The Abreva cream label says to apply it to the affected area on the face or lips at the first sign of a cold sore or fever blister, the tingle, and that early treatment ensures the best results. Rub it in gently but completely, and use it 5 times a day until the sore clears.

Keeping a tube where you can reach it quickly, such as in a bag or at work, makes it easier to start at that first sign rather than after a blister has formed.

How to apply

Allergy and other warnings

The Abreva cream label carries an allergy alert: the product may cause a severe allergic reaction, with symptoms such as hives, facial swelling, wheezing or difficulty breathing, shock or rash. If an allergic reaction occurs, stop use and seek medical help right away. Do not use it if you are allergic to any of its ingredients, which include benzyl alcohol, light mineral oil, propylene glycol, purified water, sucrose distearate and sucrose stearate.

Both products are for external use only. If swallowed, get medical help or contact a Poison Control Center right away.

When to see a doctor

Stop using Abreva cream and ask a doctor if the cold sore gets worse or has not cleared within 10 days. For the lidocaine gel, stop and ask a doctor if the condition worsens, or symptoms last more than 7 days or clear up and return within a few days.

Also see a doctor for sores near the eyes, very frequent outbreaks, sores that spread, fever, or if you have a weakened immune system. For babies and young children with mouth sores, ask a pediatrician before using any product.

Other ways to care for cold sores

Store Abreva cream at 20 to 25 C (68 to 77 F) and do not freeze it. Keep the insert, which the label says has full product uses, directions and warnings.

What to look for when you buy

Abreva docosanol 10% cream

Best for: Treating a cold sore from the first tingle

Its label lists docosanol 10% to treat cold sores and shorten how long symptoms last.

Watch out: Apply 5 times a day; see a doctor if not cleared in 10 days.

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Abreva Rapid Pain Relief gel

Best for: Numbing pain and itching

Its label lists lidocaine HCl 4% and glycerin 20% for pain, itching and softening crusts.

Watch out: Not more than 3 to 4 times daily; not over raw or blistered areas in large amounts.

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Lip balm with SPF

Best for: Protecting lips from sun and wind

Lip care between outbreaks helps keep lips protected; use a separate balm during an outbreak.

Watch out: Do not share lip products.

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When to talk to a doctor: See a doctor for cold sores near the eyes, sores that spread or last more than 10 days, fever, frequent outbreaks, or a weakened immune system. Stop and get help for signs of a severe allergic reaction.

Questions people ask

When should I start Abreva?
At the first sign of a cold sore, the tingle; the label says early treatment ensures the best results.
How often do I apply cold sore cream?
Abreva docosanol cream: 5 times a day until the sore clears, per the label.
Does Abreva numb the pain?
The original cream treats the sore; Abreva Rapid Pain Relief adds lidocaine 4% for numbing.
When should I see a doctor for a cold sore?
If it gets worse or has not cleared within 10 days, or is near the eyes.
Can kids use Abreva?
The labels say ask a doctor for children under 12.
Can I put makeup or lip balm over Abreva?
Ask a pharmacist; the label says apply only to affected areas and do not share the product, so use your own separate products.

Sources

Sources checked 2026-10-15.