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Pepto-Bismol guide: Original vs Ultra vs caplets, doses and warnings

By the Life in Good Form editors. Updated 2026-10-15.

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Quick answerPepto-Bismol's active ingredient is bismuth subsalicylate, an upset stomach reliever and antidiarrheal. Original liquid has 525 mg per 30 mL dose, Ultra liquid has 525 mg in a 15 mL dose, and caplets have 262 mg each with 2 caplets per dose. The labels list relief of diarrhea, travelers' diarrhea, and upset stomach from overindulgence, including heartburn, indigestion, nausea, gas, belching and fullness. Do not exceed 8 doses in 24 hours. It contains salicylate, so avoid it with aspirin allergy, and children and teens recovering from chickenpox or flu-like symptoms should not use it.
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Three Pepto-Bismol forms compared

FormBismuth subsalicylate per doseAdult dose and daily limit
Original liquid525 mg in 30 mL30 mL every half hour as needed; max 8 doses (240 mL) in 24 hours
Ultra liquid525 mg in 15 mL15 mL every half hour as needed; max 8 doses (120 mL) in 24 hours
Caplets262 mg per caplet; 2 caplets per dose2 caplets every half hour as needed; max 8 doses (16 caplets) in 24 hours

Details are from each product's DailyMed label, for adults and children 12 and over. For diarrhea, the labels also allow 2 doses every hour. Caplets should be swallowed with water, not chewed.

What Pepto-Bismol treats

The labels list the purpose as upset stomach reliever and antidiarrheal. Uses include travelers' diarrhea, diarrhea, and upset stomach due to overindulgence in food and drink, including heartburn, indigestion, nausea, gas, belching and fullness.

For diarrhea, use it until diarrhea stops but not more than 2 days, and drink plenty of clear fluids to help prevent dehydration. For a loperamide comparison, see our anti-diarrheal guide; for heartburn-only relief, our antacid chewables guide.

Salicylate and Reye's syndrome warnings

Medicines and conditions to ask about

Ask a doctor before use if you have a fever or mucus in the stool. Ask a doctor or pharmacist before use if you take any drug for anticoagulation (thinning the blood), diabetes, gout or arthritis. If pregnant or breastfeeding, ask a health professional before use.

Stop use and ask a doctor if symptoms get worse or last more than 2 days, ringing in the ears or loss of hearing occurs, or diarrhea lasts more than 2 days.

The black tongue and stool

The labels say a temporary, but harmless, darkening of the stool and/or tongue may occur when using this product. This is expected and different from the black, tarry stool of bleeding; if you have black stool before taking it, or other signs of bleeding such as vomiting blood, do not use it and get medical care.

For gas alone, see our simethicone gas relief guide, and for nausea, our ginger chews guide.

Sodium, minerals and dyes

If you watch sodium or other minerals, the labels list small amounts per dose. Each 30 mL dose of Original liquid contains magnesium 3 mg and sodium 4 mg and is labeled low sodium. Each 15 mL dose of Ultra contains magnesium 3 mg and sodium 2 mg. Each caplet contains calcium 27 mg and is also labeled low sodium. The pink color comes from dyes listed among the inactive ingredients, such as D&C Red No. 22 and D&C Red No. 28 in the Original liquid, so check the list if you avoid certain dyes. The Original liquid is also sweetened with sucralose.

Using it safely

What to look for when you buy

Pepto-Bismol Original liquid

Best for: Upset stomach and diarrhea

Its label lists bismuth subsalicylate 525 mg per 30 mL dose.

Watch out: Not for children or teens recovering from chickenpox or flu-like symptoms.

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Pepto-Bismol Ultra liquid

Best for: A smaller dose volume

Its label lists the same 525 mg in a 15 mL dose.

Watch out: Max 8 doses (120 mL) in 24 hours.

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Pepto-Bismol caplets

Best for: Travel and on-the-go

Its label lists bismuth subsalicylate 262 mg per caplet, 2 caplets per dose.

Watch out: Swallow with water; do not chew.

See options on Amazon
When to talk to a doctor: Do not use with bloody or black stool, an ulcer or a bleeding problem. See a doctor if symptoms last more than 2 days or ringing in the ears occurs.

Questions people ask

What is the active ingredient in Pepto-Bismol?
Bismuth subsalicylate, an upset stomach reliever and antidiarrheal.
Why does Pepto-Bismol turn my tongue black?
The label says a temporary, harmless darkening of the stool and/or tongue may occur.
Can kids take Pepto-Bismol?
Under 12, ask a doctor; children and teens recovering from chickenpox or flu-like symptoms should not use it.
Can I take Pepto-Bismol with aspirin?
No. It contains salicylate; do not take it with other salicylate products or if allergic to aspirin.
How much Pepto-Bismol can I take in a day?
No more than 8 doses in 24 hours, per the labels.
How long can I take Pepto-Bismol for diarrhea?
Use it until diarrhea stops but not more than 2 days, and see a doctor if it lasts longer.

Sources

Sources checked 2026-10-15.