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Retinol serum: how to start, which strength, and who should skip it

By the Life in Good Form editors. Updated 2026-10-15.

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Quick answerRetinol is a vitamin A-based retinoid that the American Academy of Dermatology (AAD) says is routinely used to improve uneven skin tone, pigmentation and texture. Start with the lowest formulation you can find, use it every other night at first, apply it at night, and wear sunscreen by day because retinoids can make skin more sensitive to the sun. The Ordinary, for example, suggests starting with its 0.2% retinol before moving to 0.5% and 1%. Do not use retinoids during pregnancy.
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What retinol is

The AAD describes retinoids as a catch-all term for vitamin A-based products used on skin, and retinol as a type of retinoid that is routinely used to improve uneven skin tone, pigmentation and texture. The AAD notes retinol is available over the counter in many products, and that adapalene, a retinoid for acne, comes in both prescription and over-the-counter forms.

The Ordinary describes retinol as an ingredient that improves the appearance of fine lines that can arise from a loss of collagen and elastin, while evening the appearance of texture and tone.

The Ordinary's 0.5% serum lists squalane, caprylic/capric triglyceride, jojoba seed oil and retinol among its ingredients, and describes it as water-free and alcohol-free, with squalane to help skin better withstand the drying effects of retinol.

Choosing a strength

The Ordinary serumStrengthMaker guidance
Retinol 0.2% in Squalane0.2%Where The Ordinary suggests starting
Retinol 0.5% in Squalane0.5%An intermediate formulation, water-free, in 30ml
Retinol 1% in Squalane1%Work up to it slowly

Details are from The Ordinary's product page. The AAD notes there is no standard requirement that the percentage of retinol be disclosed on a label, and advises using the lowest formulation you can find. Products that do state a percentage make it easier to start low.

Some retinol serums are built around a specific concern. CeraVe says its Resurfacing Retinol Serum, developed with dermatologists for post-acne skin, uses encapsulated retinol to help resurface skin, licorice root extract to help brighten its appearance, three essential ceramides to help restore the protective barrier, and niacinamide, which it says may help calm skin and reduce water loss. Like other cosmetic retinol products, it does not list a retinol percentage on the page, so the AAD's advice to start slowly still applies.

How to start

Sun protection

The Ordinary notes that retinoids can make the skin more sensitive to UV radiation and that sun protection is particularly important when using them. The AAD adds that if you have sensitive skin, a physical sunscreen with titanium dioxide and/or zinc oxide is a good choice; see our mineral sunscreen guide.

Pair retinol with a simple routine. For a morning serum, see our vitamin C serum guide, and for moisture, our facial moisturizer guide.

Who should be careful

If irritation happens

If your skin gets irritated, the AAD's advice applies: start slowly and use moisturizer. Stop a product that makes your skin painful, swollen or very red, and see a dermatologist if irritation does not settle or if you want a stronger prescription retinoid.

For other exfoliating products and how they differ, see our exfoliating toner pads guide.

What to look for when you buy

The Ordinary Retinol 0.2% in Squalane

Best for: First-time retinol users

The Ordinary suggests starting with its 0.2% retinol before working up to higher strengths.

Watch out: Use at night and wear sunscreen by day.

See options on Amazon

The Ordinary Retinol 0.5% in Squalane

Best for: People who tolerate a lower strength

The Ordinary lists a water-free 0.5% retinol with squalane in 30ml.

Watch out: Do not combine with other retinoids, per The Ordinary.

See options on Amazon

CeraVe Resurfacing Retinol Serum

Best for: Post-acne marks and texture

CeraVe lists encapsulated retinol with licorice root extract, three ceramides and niacinamide.

Watch out: No retinol percentage on the page; start every other night.

See options on Amazon
When to talk to a doctor: Do not use retinoids during pregnancy. Stop a retinol product that causes painful, swollen or very red skin, and see a dermatologist for irritation that does not settle.

Questions people ask

What does retinol do?
The AAD says retinol is routinely used to improve uneven skin tone, pigmentation and texture.
How often should I use retinol at first?
An AAD dermatologist advises every other night to start, building up slowly.
Which strength should I start with?
The lowest you can find, per the AAD; The Ordinary suggests starting at 0.2%.
Can I use retinol while pregnant?
No. The AAD says retinoids should not be used during pregnancy.
Do I need sunscreen with retinol?
Yes. Retinoids can make skin more sensitive to the sun, so wear sunscreen every day.

Sources

Sources checked 2026-10-15.