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Lice treatment for kids

By the Life in Good Form editors. Updated 2026-10-15.

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Quick answerThe two main over-the-counter head lice treatments are permethrin 1% creme rinse (Nix), approved for children 2 months and older, and pyrethrins with piperonyl butoxide (RID), approved for children 2 years and older. Neither reliably kills unhatched eggs, so the CDC advises combing out nits and treating again about 9 to 10 days later, or when live lice are seen 7 or more days after treatment, as the Nix label says. Treat everyone who has lice at the same time, and skip conditioner before treatment.
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Comparing the two OTC treatments

ProductActive ingredient and ageHow it is applied
Nix Creme RinsePermethrin 1%; 2 months and olderOn shampooed, towel-damp hair for 10 minutes, then rinse
RID Lice Killing ShampooPyrethrins 0.33% with piperonyl butoxide 4%; 2 years and olderOn dry hair for 10 minutes, then lather and rinse

Details are from each product's Drug Facts label on DailyMed; ages match the CDC's clinical care page. The CDC says pyrethrins kill only live lice, not unhatched eggs, and that permethrin kills live lice but not unhatched eggs, which is why retreatment matters.

Check everyone first

The Nix label says all household members should be checked by another person. Use a magnifying glass in bright light, part the hair in small sections 1 to 2 inches wide, and look for tiny nits near the scalp, starting at the back of the neck and behind the ears. Unlike dandruff, which moves when touched, nits stick to the hair. The CDC says to treat all infested household members, close contacts and anyone who shares a bed at the same time.

Applying the treatment

Nit combing

Both labels direct you to comb out lice and nits with a fine-tooth nit comb while the hair is slightly damp, re-wetting it if it dries. The RID label says to work in sections starting on top of the head, lifting a 1 to 2 inch strand and combing from as close to the scalp as possible; on longer hair this may take 1 to 2 hours. Remaining nits can be removed by hand using a throw-away glove.

The CDC advises checking hair and removing nits and lice every 2 to 3 days for 2 to 3 weeks after treatment.

Retreatment and when to call a doctor

The CDC says to treat a second time 9 to 10 days after the first pyrethrin treatment, and that with permethrin you may need to treat again on day nine, to kill newly hatched lice before they lay eggs. The Nix label says to give a second treatment if live lice are seen seven days or more after the first.

If lice persist, ask a provider about prescription options. The CDC lists ivermectin lotion 0.5% for people 6 months and older, spinosad for children 6 months and older, and malathion for people 6 years and older.

Warnings and home cleaning

What to look for when you buy

Nix Lice Killing Creme Rinse

Best for: Children 2 months and older

Its label lists permethrin 1%, left on damp hair for 10 minutes, with a nit comb.

Watch out: Ask a doctor first if allergic to ragweed.

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RID Lice Killing Shampoo

Best for: Children 2 years and older

Its label lists pyrethrins with piperonyl butoxide, applied to dry hair for 10 minutes.

Watch out: Retreat 9 to 10 days later, per the CDC.

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Metal nit comb

Best for: Removing nits after treatment

Both labels and the CDC rely on nit combing to remove eggs the medicine may not kill.

Watch out: Comb damp hair in small sections.

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When to talk to a doctor: See a doctor for lice in the eyebrows or eyelashes, scalp infection, breathing trouble after treatment, or lice that persist after two treatments.

Questions people ask

What is the youngest age for lice treatment?
The CDC says permethrin is approved from 2 months and pyrethrins from 2 years.
Do lice treatments kill eggs?
The CDC says permethrin and pyrethrins kill live lice but not unhatched eggs, so comb and retreat.
When should I retreat for lice?
The CDC says 9 to 10 days after pyrethrins, or about day nine with permethrin.
Can I use conditioner before lice treatment?
No. The CDC and Nix label say conditioner can make the medicine less effective.
Do I need to clean the whole house?
The CDC suggests hot washing items used in the last 2 days, bagging others for 2 weeks and vacuuming; no fogs.

Sources

Sources checked 2026-10-15.